A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

Abstract

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl₂ has been developed.

DOI: 10.3762/bjoc.6.120

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Cite this paper

@inproceedings{Moirangthem2010ANA, title={A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative}, author={Nimalini Devi Moirangthem and Warjeet Singh Laitonjam}, booktitle={Beilstein journal of organic chemistry}, year={2010} }