• DOI:10.1016/j.bmcl.2010.11.017
Corpus ID: 27483406

A new and efficient synthetic route for the anxiolytic agent CL285032.

@article{Ghidu2011ANA,
  title={A new and efficient synthetic route for the anxiolytic agent CL285032.},
  author={Victor P. Ghidu and M. Ilies and T. Cullen and Robert Pollet and M. Abou-Gharbia},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 1},
  pages={
          259-61
        }
}

Victor P. Ghidu, M. Ilies, +2 authors M. Abou-Gharbia

Published 2011

Chemistry, Medicine

Bioorganic & medicinal chemistry letters

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CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.