A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats.

@article{Fukuyama1994ANA,
  title={A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats.},
  author={Takako Fukuyama and Kiyoshi Yamaoka and Yasushi Ohata and Tomoka Nakagawa},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1994},
  volume={22 3},
  pages={479-85}
}
The pharmacokinetics of diclofenac, which is definitely subject to enterohepatic circulation in rats, was evaluated. The pharmacokinetic model for enterohepatic circulation was constructed in the Laplace-transformed domain by means of the transfer function method of the signal flow. The transformed equations were simultaneously fitted to the time courses of plasma concentration averaged over two groups of rats [i.e. one with an intact enterohepatic circulation and the other without an… CONTINUE READING

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The experiments using bile duct cannulation revealed that the total amounts excreted into the bile were 14.4% in the anesthetized group and 40.4% in the nonanesthetized group of rats , and that diclofenac was excreted 95% as the glucuronide form and 5% as the intact form in both groups .
The experiments using bile duct cannulation revealed that the total amounts excreted into the bile were 14.4% in the anesthetized group and 40.4% in the nonanesthetized group of rats , and that diclofenac was excreted 95% as the glucuronide form and 5% as the intact form in both groups .
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