A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia

@article{Tomiyama2008ANA,
  title={A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia},
  author={T. Tomiyama and T. Nagata and H. Shimada and Rie Teraoka and A. Fukushima and Hyoue Kanemitsu and H. Takuma and R. Kuwano and M. Imagawa and S. Ataka and Yasuhiro Wada and Eito Yoshioka and T. Nishizaki and Y. Watanabe and H. Mori},
  journal={Annals of Neurology},
  year={2008},
  volume={63}
}
Soluble oligomers of amyloid β (Aβ), rather than amyloid fibrils, have been proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease (AD). However, there is no direct evidence in humans that this mechanism can cause AD. Here, we report a novel amyloid precursor protein (APP) mutation that may provide evidence to address this question. 
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