A new amyloid β variant favoring oligomerization in Alzheimer's‐type dementia

  title={A new amyloid $\beta$ variant favoring oligomerization in Alzheimer's‐type dementia},
  author={Takami Tomiyama and Tetsu Nagata and Hiroyuki Shimada and Rie Teraoka and Akiko Fukushima and Hyoue Kanemitsu and Hiroshi Takuma and Ryozo Kuwano and Masaki Imagawa and Suzuka Ataka and Yasuhiro Wada and Eito Yoshioka and Tomoyuki Nishizaki and Yasuyoshi Watanabe and Hiroshi Mori},
  journal={Annals of Neurology},
Soluble oligomers of amyloid β (Aβ), rather than amyloid fibrils, have been proposed to initiate synaptic and cognitive dysfunction in Alzheimer's disease (AD). However, there is no direct evidence in humans that this mechanism can cause AD. Here, we report a novel amyloid precursor protein (APP) mutation that may provide evidence to address this question. 
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