A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.

@article{Omura1977ANA,
  title={A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.},
  author={Satoshi O̅mura and Yuzuru Iwai and Atsushi Hirano and Akira Nakagawa and Jonathan D. Awaya and H Tsuchya and Yōko Takahashi and Rokuro Masuma},
  journal={The Journal of antibiotics},
  year={1977},
  volume={30 4},
  pages={275-82}
}
AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA… CONTINUE READING