A new adaptive design based on Simon's two-stage optimal design for phase II clinical trials.

@article{Jin2012ANA,
  title={A new adaptive design based on Simon's two-stage optimal design for phase II clinical trials.},
  author={Hua Jin and Zhanghong Wei},
  journal={Contemporary clinical trials},
  year={2012},
  volume={33 6},
  pages={1255-60}
}
Phase II clinical trials are conducted to determine whether a new agent or drug regimen has sufficient promise in treating cancer to merit further testing in larger groups of patients. Both ethical and practical considerations often require early termination of phase II trials if early results clearly indicate that the new regimen is not active or worthy of further investigation. Simon's two-stage designs (1989) are common methods for conducting phase II studies investigating new cancer… CONTINUE READING

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