A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

@article{Besmer1986ANA,
  title={A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family},
  author={Peter Besmer and John Murphy and Patricia C. George and Feihua Qiu and Peter J Bergold and Lynn Lederman and H. W. Snyder and David Brodeur and Evelyn E. Zuckerman and William David Hardy},
  journal={Nature},
  year={1986},
  volume={320},
  pages={415-421}
}
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5′ ▵gag-kit-▵pol-▵env 3′ and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction… CONTINUE READING
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