A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects

@article{Amakawa2015ANX,
  title={A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects},
  author={Yuko Amakawa and Yuka Sakata and Yuko Hoki and Satoru Arata and Seiji Shioda and Tatsuo Fukagawa and Hiroyuki Sasaki and Takashi Sado},
  journal={Development},
  year={2015},
  volume={142},
  pages={4299 - 4308}
}
The dosage difference of X-linked genes between the sexes in mammals is compensated for by genetic inactivation of one of the X chromosomes in XX females. A noncoding RNA transcribed from the Xist gene at the onset of X chromosome inactivation coats the X chromosome in cis and induces chromosome-wide heterochromatinization. Here, we report a new Xist allele (XistCAG) driven by a CAG promoter, which is known to be constitutively active in many types of cells. The paternal transmission of XistCAG… 
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