A new Salmonella tester strain expressing a hamster acetyltransferase shows high sensitivity for arylamines.

@article{Ando1993ANS,
  title={A new Salmonella tester strain expressing a hamster acetyltransferase shows high sensitivity for arylamines.},
  author={Miki Ando and Yasuhiro Shindo and Masahiro Fujita and Shogo Ozawa and Y. Yamazoe and Reike Kato},
  journal={Mutation research},
  year={1993},
  volume={292 2},
  pages={155-63}
}
A hamster acetyltransferase, AT-I, has high activities for N-acetylation of arylamines, O-acetylation of N-hydroxyarylamines and N,O-acetyltransfer of N-hydroxyarylacetamides. In the present study, the cDNA was expressed in Salmonella typhimurium TA1538. The new SAT138 strain expressing high levels of AT-I showed remarkably high sensitivity (> 10,000 fold) for a carcinogenic intermediate, N-hydroxy-2-acetylaminofluorene, in an Ames mutagenesis test as compared to the parental TA1538 strain… CONTINUE READING