A new SIMS paradigm for 2D and 3D molecular imaging of bio-systems.

@article{Fletcher2010ANS,
  title={A new SIMS paradigm for 2D and 3D molecular imaging of bio-systems.},
  author={John S Fletcher and John C. Vickerman},
  journal={Analytical and bioanalytical chemistry},
  year={2010},
  volume={396 1},
  pages={85-104}
}
With the implementation of focused primary ion beams, secondary ion mass spectrometry (SIMS) has become a significant technique in the rapidly emerging field of mass spectral imaging in the biological sciences. Liquid metal ion guns (LMIG) offered the prospect of sub-100 nm spatial resolution, however this aspiration has yet to be reached for molecular imaging. This brief review shows that using LMIG the limitations of the static limit and low ionization probability will restrict useful imaging… CONTINUE READING
12 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.

A new SIMS paradigm for 2D and 3D molecular imaging of bio-systems

  • D Tomboul, F Kollmer, E Niehuis, A Brunelle, O Laprévote
  • J Am Soc Mass Spectrom
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…