A new Na/Ca exchanger splicing pattern identified in situ leads to a functionally active 70kDa NH(2)-terminal protein.


The Na/Ca exchanger (NCX) is an ubiquitous transporter that plays an important role in regulating cellular Ca(2+) balance. On gel electrophoresis, the NCX1 protein migrates as two major bands of 120 and 70kDa. While the 120kDa is thought to represent the native protein, the nature of the 70kDa protein remains unclear. In this report, we describe a new NCX1… (More)