A new N-glucuronide metabolite of carbamazepine

  title={A new N-glucuronide metabolite of carbamazepine},
  author={J. E. Bauer and Nicholas Gerber and Robert K. Lynn and R. G. Smith and R. Mac Thompson},
An N-glucuronide metabolite of carbamazepine was identified in the bile of the isolated perfused rat liver by means of permethylation, gas chromatography and mass spectrometry. 
N-Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7
A sensitive liquid chromatography/mass spectrometry assay is developed and reported that CBZ is specifically glucuronidated by human UGT2B7, and this is the first example of primary amine glucuronidation by UGT1B7. Expand
Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects
It is demonstrated that glucuronide conjugation plays a minor role in the metabolism ofCBZ and CBZ-E in humans, and that probenecid has an inducing effect on the disposition of CBZ. Expand
Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal.
Explicit care was taken to achieve a good chromatographic separation of the numerous isomers that were difficult to distinguish by mass spectrometry alone, and a phenylether stationary phase provided the best separation. Expand
Entwicklung und Validierung eines Enzyme-linked Immunosorbent Assays (ELISA) für die Quantifizierung von Carbamazepin in Abwasser, Oberflächenwasser und Trinkwasser
A competitive ELISA (enzyme-linked immunosorbent assay) for the quantitation of carbamazepine (CBZ) was developed and validated. A limit of quantitation (LOQ) of ca. 30 ng/L allowed for theExpand
Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response
The most important pharmacogenetic finding is related to the association of CBZ-induced hypersensitivity with human leukocyte antigens (HLA class I and II alleles) and genotypes for HLA-B*15:02 allele is required prior to initiating CBZ in Asians and Asian ancestry patients, demonstrating the usefulness of biomarkers to avoid adverse drug reactions. Expand


Mass spectrometric characterization of carbamazepine-10,11-epoxide, a carbamazepine metabolite isolated from human urine.
Mass spectrometric characterization confirmed the structure of this metabolic product, which was postulated after comparison with the synthetic epoxide, and was identified in human urine collected after the oral administration of carbamazepine. Expand
Metabolism of methocarbamol (robaxin) in the isolated perfused rat liver and identification of glucuronides.
An interesting rearrangement of a methyl group has been found in the mass spectrum of 3-(2-methoxyphenyloxy)-1,2-dimethoxypropane, the permethylation product from methocarbamol. Expand
Study of dose-dependent metabolism of 5,5-diphenyl-hydantoin in the rat using new methodology for isolation and quantitation of metabolites in vivo and in vitro.
Pretreatment of rats with phenobarbital, chlordane, hydroxyzine and DDT results in an increase in the rate of disappearance of DPH from microsomal incubations and the metabolite pattern remains similar. Expand
Iminostilbene—a metabolite of carbamazepine isolated from rat urine