A new MAFia in cancer

  title={A new MAFia in cancer},
  author={Alain Eych{\`e}ne and Nathalie Rocques and Celio Pouponnot},
  journal={Nature Reviews Cancer},
Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer — overexpression of the large Maf genes promotes the development of multiple myeloma — they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 78 extracted citations


Publications referenced by this paper.
Showing 1-10 of 105 references

A module of negative feedback regulators defines growth factor signaling

  • I. Amit
  • Nature Genet .
  • 2007

AhR - and cmafdependent induction of β 7integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons

  • P. Monteiro
  • Biochem . Biophys . Res . Commun .
  • 2007

GSK - 3mediated phosphorylation enhances Maftransforming activity

  • N. Rocques
  • Mol . Cell
  • 2007

Similar Papers

Loading similar papers…