A new MAFia in cancer

@article{Eychne2008ANM,
  title={A new MAFia in cancer},
  author={Alain Eych{\`e}ne and Nathalie Rocques and Celio Pouponnot},
  journal={Nature Reviews Cancer},
  year={2008},
  volume={8},
  pages={683-693}
}
Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer — overexpression of the large Maf genes promotes the development of multiple myeloma — they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the… CONTINUE READING
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