A new HPLC-UV validated method for therapeutic drug monitoring of tyrosine kinase inhibitors in leukemic patients.

Abstract

Development and validation of simple, rapid, and reliable high-performance liquid chromatography (HPLC)-UV method for quantification of major tyrosine kinase inhibitors, imatinib, dasatinib, and nilotinib, in human plasma is presented. Chromatographic separation of the drugs is achieved on an RP-C(18) column at flow rate of 0.9 mL/min at 35°C; eluate is… (More)

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@article{Pirro2011ANH, title={A new HPLC-UV validated method for therapeutic drug monitoring of tyrosine kinase inhibitors in leukemic patients.}, author={Elisa Pirro and Silvia De Francia and Francesca De Martino and Carmen Fava and Stefano Ulisciani and Giovanna Rege Cambrin and Silvia Racca and Giuseppe Saglio and Francesco Di Carlo}, journal={Journal of chromatographic science}, year={2011}, volume={49 10}, pages={753-7} }