A new ELISA assay for diagnosis of acquired von Willebrand syndrome.

@article{Siaka2003ANE,
  title={A new ELISA assay for diagnosis of acquired von Willebrand syndrome.},
  author={C Siaka and Lucia Rugeri and Claudine Caron and Jenny Goudemand},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2003},
  volume={9 3},
  pages={303-8}
}
The pathophysiology of acquired von Willebrand syndrome (AVWS), a rare bleeding disorder, is not fully understood. Circulating antibodies to Von Willebrand factor (VWF) are found in patients with AVWS associated with lymphoproliferative disorders but these autoantibodies are difficult to detect with routine laboratory tests and neutralisation assays. We have developed a simple enzyme-linked immunosorbent assay (ELISA) to detect serum antibody binding to VWF protein immobilized on polystyrene… CONTINUE READING
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