A new EGF-active polymeric pyridinium alkaloid from the sponge Callyspongia fibrosa

@inproceedings{DaviesColeman1993ANE,
  title={A new EGF-active polymeric pyridinium alkaloid from the sponge Callyspongia fibrosa},
  author={Michael T. Davies-Coleman and David John Faulkner and Gene M. Dubowchik and Gregory P. Roth and Craig Polson and Craig R. Fairchild},
  year={1993}
}
An inhibitor of the epidermal growth factor (EGF) receptor was isolated from an extract of the Micronesian sponge Callyspongia fibrosa. The structure of the EGF-active compound was first proposed, on the basis of ion-spray mass spectrometry, to be the cyclic dimer 1 (n= 2) but comparison of a sample produced by an efficient synthetic route revealed that hypothesis to be incorrect. The EGF-active constituent must therefore be a large oligomer or a polymer of the same repeating subunit 1 

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