A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

@article{Mellado2007ANA,
  title={A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.},
  author={Emilia Mellado and Guillermo Garcia-Effron and Laura Alc{\`a}zar-Fuoli and Willem J G Melchers and Paul E Verweij and Manuel Cuenca-Estrella and Juan Lu{\'i}s Rodr{\'i}guez-Tudela},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 6},
  pages={
          1897-904
        }
}
Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced susceptibility to triazole drugs were analyzed. The sequences of the cyp51A gene from all isolates showed the presence of a point mutation at t364a, which led to the substitution of leucine 98 for histidine (L98H), together with the presence of two copies of a 34-bp sequence in tandem in the promoter of the cyp51A gene. Quantitative expression analysis (real-time PCR) showed up to an eightfold increase in the… CONTINUE READING

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