• Corpus ID: 30295551

A new Acanthamoeba myosin heavy chain. Cloning of the gene and immunological identification of the polypeptide.

  title={A new Acanthamoeba myosin heavy chain. Cloning of the gene and immunological identification of the polypeptide.},
  author={J A Horowitz and John A. Hammer},
  journal={The Journal of biological chemistry},
  volume={265 33},
  • J. Horowitz, J. Hammer
  • Published 25 November 1990
  • Biology, Medicine
  • The Journal of biological chemistry
An Acanthamoeba myosin heavy chain has been identified whose tail domain amino acid sequence distinguishes it from Acanthamoeba myosins IB, IC, and II. The gene for this novel myosin heavy chain spans approximately 6.8 kilobases, is split by 17 introns, and encodes a 177-kDa polypeptide. While the amino-terminal approximately 90 kDa of this polypeptide is highly similar to the globular head sequences of myosins I and II, its approximately 87-kDa tail domain shows essentially no similarity to… 
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