A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells.

@article{Wang2007ANA,
  title={A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells.},
  author={Hai Wang and Chaoliang Long and Zhibian Duan and Cuige Shi and Guodong Jia and Yingli Zhang},
  journal={Cardiovascular research},
  year={2007},
  volume={73 3},
  pages={497-503}
}
OBJECTIVE Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in endothelial dysfunction include reduced nitric oxide (NO) generation and increased endothelin-1 (ET-1) generation. Endothelial ATP-sensitive potassium (K(ATP)) channels are responsible for maintaining the resting potential of endothelial cells and modulating the release of vasoactive compounds. We hypothesized that activation of endothelial K(ATP) channels might… CONTINUE READING

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