A new, pluronic-based, bone hemostatic agent that does not impair osteogenesis.

@article{Wang2001ANP,
  title={A new, pluronic-based, bone hemostatic agent that does not impair osteogenesis.},
  author={Michael S. Y. Wang and J. Karl Armstrong and Timothy C. G. Fisher and Herbert J. Meiselman and G Mccomb and Michael L Levy},
  journal={Neurosurgery},
  year={2001},
  volume={49 4},
  pages={962-7; discussion 968}
}
OBJECTIVE Intraoperative bone hemostasis can be accomplished using surgical beeswax (bone wax). However, bone wax locally interferes with osteogenesis, and its use is avoided when bone fusion is critical. We describe the use of a Pluronic copolymer blend as a biocompatible, absorbable, hemostatic agent. METHODS A rat femur defect model and a femur gap nonunion model were used. For each surgical model, 24 rats were divided into three treatment groups, i.e., those receiving bone wax implants… CONTINUE READING

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