A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice.

Abstract

AIM We investigated how GW800644, the first pharmacologically selective murine peroxisome proliferator-activated receptor δ (PPARδ) agonist, affects energy balance, glucose homeostasis and fuel utilization by muscle in obese mice. METHODS Potencies were determined in transactivation assays. Oral glucose tolerance was determined after 14 and 22 days… (More)
DOI: 10.1111/j.1463-1326.2011.01371.x

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