A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.

@article{Li2004ANA,
  title={A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.},
  author={Weiwei Aileen Li and Lee Walus and Sylvia A Rabacchi and Adrienna Jirik and Ernie C Chang and Jessica Schauer and Betty H Zheng and Nancy J. Benedetti and Betty P. Liu and Eugene Choi and Dane S Worley and Laura Silvian and Wenjun Mo and Colleen Mullen and Weixing Yang and Stephen M Strittmatter and Dinah W. Y. Sah and Blake Pepinsky and Daniel Hong Seng Lee},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 42},
  pages={43780-8}
}
The Nogo66 receptor (NgR1) is a neuronal, leucine-rich repeat (LRR) protein that binds three central nervous system (CNS) myelin proteins, Nogo, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein, and mediates their inhibitory effects on neurite growth. Although the LRR domains on NgR1 are necessary for binding to the myelin proteins, the exact epitope(s) involved in ligand binding is unclear. Here we report the generation and detailed characterization of an anti-NgR1… CONTINUE READING

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