A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration

@article{Shankaran1999ANR,
  title={A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration},
  author={Mahalakshmi Shankaran and Gary A. Gudelsky},
  journal={Psychopharmacology},
  year={1999},
  volume={147},
  pages={66-72}
}
  • Mahalakshmi Shankaran, Gary A. Gudelsky
  • Published in Psychopharmacology 1999
  • Psychology, Medicine
  • Abstract Rationale: 3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. Objective: The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body temperature and the 5-HT behavioral syndrome in rats 7 days following a neurotoxic regimen of MDMA. Methods: One week after the rats were treated with a neurotoxic… CONTINUE READING

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