A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity.

@article{Salmona1997ANA,
  title={A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity.},
  author={Mario Salmona and Gianluigi Forloni and Luisa Diomede and M Algeri and Luca de Gioia and Nadia Angeretti and Giorgio Giaccone and F. Tagliavini and Orso Bugiani},
  journal={Neurobiology of disease},
  year={1997},
  volume={4 1},
  pages={47-57}
}
Prion-related encephalopathies are characterized by astrogliosis and nerve cell degeneration and loss. These lesions might be the consequence of an interaction between the abnormal isoform of the cellular prion protein that accumulates in nervous tissue and the plasma membranes. Previously we found that a synthetic peptide, homologous to residues 106-126 of… CONTINUE READING