A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury

@article{Iannotti2004ANR,
  title={A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury},
  author={Christopher A. Iannotti and Yi Ping Zhang and Christopher B Shields and Yingchun Han and Xiao-Ming Xu},
  journal={Experimental Neurology},
  year={2004},
  volume={189},
  pages={317-332}
}
The present study investigated neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-beta (TGF-beta) superfamily, following moderate contusive spinal cord injury (SCI) in adult rats. A T11 spinal cord contusion injury was made using an Infinite Horizon impactor (IH; impact force=150 kDyn) and recombinant human GDNF at two concentrations (rhGDNF; 1 or 5 microg/microl), or saline vehicle was delivered intrathecally for 28… CONTINUE READING

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