A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.

@article{Sompol2008ANM,
  title={A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.},
  author={Pradoldej Sompol and Wanida Ittarat and Jitbanjong Tangpong and Y Chen and Irina Doubinskaia and Ines Batini{\'c}-Haberle and Hafiz Mohmmad Abdul and David Butterfield and Daret K. St. Clair},
  journal={Neuroscience},
  year={2008},
  volume={153 1},
  pages={120-30}
}
Alzheimer's disease (AD) is associated with beta-amyloid accumulation, oxidative stress and mitochondrial dysfunction. However, the effects of genetic mutation of AD on oxidative status and mitochondrial manganese superoxide dismutase (MnSOD) production during neuronal development are unclear. To investigate the consequences of genetic mutation of AD on oxidative damages and production of MnSOD during neuronal development, we used primary neurons from new born wild-type (WT/WT) and amyloid… CONTINUE READING
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NF-kappaBassociated MnSOD induction protects against beta-amyloid-induced neuronal apoptosis

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