A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.

@article{Lajoix2001ANI,
  title={A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.},
  author={Anne Dominique Lajoix and Hubert Reggio and Thierry Chard{\`e}s and Sylvie P{\'e}raldi-Roux and Florence Tribillac and Marcia E. Roye and Samuel Dietz and Christophe Broca and Mich{\`e}le Manteghetti and G{\'e}rard Ribes and Claes B Wollheim and Ren{\'e} Gross},
  journal={Diabetes},
  year={2001},
  volume={50 6},
  pages={1311-23}
}
Evidence is presented showing that a neuronal isoform of nitric oxide synthase (NOS) is expressed in rat pancreatic islets and INS-1 cells. Sequencing of the coding region indicated a 99.8% homology with rat neuronal NOS (nNOS) with four mutations, three of them resulting in modifications of the amino acid sequence. Double-immunofluorescence studies demonstrated the presence of nNOS in insulin-secreting beta-cells. Electron microscopy studies showed that nNOS was mainly localized in insulin… CONTINUE READING

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