A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases.

@article{Aihara2003ANE,
  title={A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases.},
  author={Koutoku Aihara and Shigetoshi Kuroda and Norihiro Kanayama and Shogo Matsuyama and Katsuyuki Tanizawa and Masato Horie},
  journal={Brain research. Molecular brain research},
  year={2003},
  volume={116 1-2},
  pages={
          86-93
        }
}
NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains. NELL2 is highly expressed in the hippocampus and cerebral cortex. Although the involvement of NELL2 in neural functions has been inferred from its expression and biochemical profiles, biological roles of NELL2 remain uncertain. We evaluated the survival effect of NELL2 using primary cultured neurons from fetal rat brain following treatment with a recombinant NELL2 protein… CONTINUE READING
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