A neuroinformatics study describing molecular interaction of Cisplatin with acetylcholinesterase: a plausible cause for anticancer drug induced neurotoxicity.

@article{Baig2014ANS,
  title={A neuroinformatics study describing molecular interaction of Cisplatin with acetylcholinesterase: a plausible cause for anticancer drug induced neurotoxicity.},
  author={Mohd. Hassan Baig and Syed Mohd Danish Rizvi and Shazi Shakil and Mohammad Amjad Kamal and Saif Khan},
  journal={CNS & neurological disorders drug targets},
  year={2014},
  volume={13 2},
  pages={265-70}
}
Several chemotherapeutic drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to understand the toxicity of these drugs at the molecular and cellular levels. This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well-known anti-neoplastic drug, Cisplatin. Docking between Cisplatin and AChE was performed using… CONTINUE READING