A neuroendocrine role in cocaine reinforcement.

  title={A neuroendocrine role in cocaine reinforcement.},
  author={Nicholas E. Goeders},
  volume={22 4},
Cocaine stimulates the secretion of corticosterone and ACTH, probably through a CRF-related mechanism, indicating that the drug activates the HPA axis. Indeed, cocaine has been reported to produce anxiety and to precipitate episodes of panic attack during chronic use and withdrawal in humans and to induce anxiogenic behavior in animals. Cocaine also alters benzodiazepine receptor binding in discrete regions of the rat brain. Some of these changes in binding are obviously related to the… CONTINUE READING
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