A neuroendocrine mechanism for sustaining fear

  title={A neuroendocrine mechanism for sustaining fear},
  author={Jay Schulkin and Maria A. Morgan and Jeffrey B Rosen},
  journal={Trends in Neurosciences},
Fear is an adaptive response to recognition of a potentially dangerous event. Glucocorticoids are essential for maintaining a wide variety of behavioral events by their regulation of numerous genes; one such gene encodes corticotrophin-releasing hormone (CRH). CRH is involved in diverse behavioral responses to changing environmental demands. In this review, we focus on one aspect of glucocorticoid regulation of CRH--namely, fear-related responses to diverse classes of adverse events, such as… CONTINUE READING


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