A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

  title={A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms},
  author={J. Hall and H. Whalley and D. Job and B. J. Baig and A. McIntosh and K. Evans and P. Thomson and D. Porteous and D. G. Cunningham-Owens and E. Johnstone and S. Lawrie},
  journal={Nature Neuroscience},
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ. 
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