A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

  title={A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms},
  author={Jeremy Hall and Heather C. Whalley and Dominic Edward Job and Benjamin Jacob Baig and Andrew M. McIntosh and Kathryn L. Evans and Pippa A. Thomson and David J. Porteous and David G. Cunningham-Owens and Eve C. Johnstone and Stephen M. Lawrie},
  journal={Nature Neuroscience},
NRG1, encoding neuregulin 1, is a susceptibility gene for schizophrenia, but no functional mutation causally related to the disorder has yet been identified. Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. We show that this variant is associated with (i) decreased activation of frontal and temporal lobe regions, (ii) increased development of psychotic symptoms and (iii) decreased premorbid IQ. 
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