A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.

Abstract

Fbs1 is an F-box protein present abundantly in the nervous system. Similar to the ubiquitously expressed Fbs2, Fbs1 recognizes N-glycans at the innermost position as a signal for unfolded glycoproteins, probably in the endoplasmic reticulum-associated degradation pathway. Here, we show that the in vivo majority of Fbs1 is present as Fbs1-Skp1 heterodimers… (More)

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Cite this paper

@article{Yoshida2007ANF, title={A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.}, author={Yukiko Yoshida and Arisa Murakami and Kazuhiro Iwai and Keiji Tanaka}, journal={The Journal of biological chemistry}, year={2007}, volume={282 10}, pages={7137-44} }