A network perspective on the topological importance of enzymes and their phylogenetic conservation

@article{Liu2006ANP,
  title={A network perspective on the topological importance of enzymes and their phylogenetic conservation},
  author={Wei-Chung Liu and Wen-hsien Lin and Andrew J. Davis and Ferenc Jord{\'a}n and Hsih-te Yang and Ming-Jing Hwang},
  journal={BMC Bioinformatics},
  year={2006},
  volume={8},
  pages={121 - 121}
}
A metabolic network is the sum of all chemical transformations or reactions in the cell, with the metabolites being interconnected by enzyme-catalyzed reactions. Many enzymes exist in numerous species while others occur only in a few. We ask if there are relationships between the phylogenetic profile of an enzyme, or the number of different bacterial species that contain it, and its topological importance in the metabolic network. Our null hypothesis is that phylogenetic profile is independent… CONTINUE READING
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