A network of networks: cytoskeletal control of compartmentalized function within dendritic spines.

@article{Frost2010ANO,
  title={A network of networks: cytoskeletal control of compartmentalized function within dendritic spines.},
  author={Nicholas A. Frost and Justin M Kerr and Hsiangmin E. Lu and Thomas A. Blanpied},
  journal={Current opinion in neurobiology},
  year={2010},
  volume={20 5},
  pages={578-87}
}
Almost 30 years ago, actin was identified as the major cytoskeletal component of dendritic spines. Since then, its role in the remarkable dynamics of spine morphology have been detailed with live-cell views establishing that spine shape dynamics are an important requirement for synaptogenesis and synaptic plasticity. However, the actin cytoskeleton is critical to numerous and varied processes within the spine which contribute to the maintenance and plasticity of synaptic function. Here, we… CONTINUE READING

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