A network of fast-spiking cells in the neocortex connected by electrical synapses

@article{Galarreta1999ANO,
  title={A network of fast-spiking cells in the neocortex connected by electrical synapses},
  author={Mario Galarreta and Shaul Hestrin},
  journal={Nature},
  year={1999},
  volume={402},
  pages={72-75}
}
Encoding of information in the cortex is thought to depend on synchronous firing of cortical neurons. Inhibitory neurons are known to be critical in the coordination of cortical activity, but how interaction among inhibitory cells promotes synchrony is not well understood. To address this issue directly, we have recorded simultaneously from pairs of fast-spiking (FS) cells, a type of γ-aminobutyric acid (GABA)-containing neocortical interneuron. Here we report a high occurrence of electrical… 
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Synchronization in a network of fast-spiking interneurons.
TLDR
By using a biophysical model of FS interneurons the synchronization properties of a network of two synaptically coupled units are investigated and well defined regions exist in the parameters space described by the strength and duration of the synaptic current, where synchronous regimes occur.
Neocortical Fast-Spiking interneurons : model , dynamical behaviour and synchronization properties
Neocortical inhibitory Fast-Spiking interneurons are interconnected by electrical synapses (gap-junctions) and control the spike discharge of pyramidal neurons. In this report, by using a biophysical…
Synaptogenesis of Electrical and GABAergic Synapses of Fast-Spiking Inhibitory Neurons in the Neocortex
TLDR
It is found that synaptogenesis of electrical and GABAergic connections of FS cells takes place in the same period, suggesting that chemical and electrical connections among FS cells can contribute to patterned neocortical activity only by the end of the first postnatal week.
Two dynamically distinct inhibitory networks in layer 4 of the neocortex.
TLDR
There are two parallel but dynamically distinct systems of synaptic inhibition in layer 4 of neocortex, each defined by its intrinsic spiking properties, the short-term plasticity of its chemical synapses, and an exclusive set of electrical synapses.
Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4.
TLDR
The results imply that the generation of ePSPs is predominantly a linear process in both cell types for presynaptic firing of both single and repetitive spikes, and that electrical coupling between 2 inhibitory cells promotes synchrony at all spiking frequencies.
Spike Transmission and Synchrony Detection in Networks of GABAergic Interneurons
TLDR
Using paired recordings in rat neocortical slices, it is found that the firing of fast-spiking cells can reflect the spiking pattern of single-axon pyramidal inputs, and this property allowed groups ofFast-Spiking cells interconnected by electrical and γ-aminobutyric acid (GABA)–releasing ( GABAergic) synapses to detect the relative timing of their excitatory inputs.
Fast Spiking Cells and the Balance of Excitation and Inhibition in the Neocortex
Excitatory glutamatergic neurons largely outnumber inhibitory ones and account for about 80% of the cells in the neocortex. In addition, the axonal collaterals of excitatory neurons make large number…
A Role for Electrotonic Coupling Between Cortical Pyramidal Cells
TLDR
It is shown that electrical coupling among pyramidal-cell pairs significantly enhances coincidence-detection capabilities and increases network spike-timing precision, and a network containing multiple pairs exhibits large variability in its firing pattern, possessing a rich coding structure.
Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex
  • M. Galarreta, S. Hestrin
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
TLDR
The results indicate that PV-FS cells are highly interconnected in the adult cerebral cortex by both electrical and chemical synapses, establishing networks that can have important implications for coordinating activity in cortical circuits.
Synchrony of fast-spiking interneurons interconnected by GABAergic and electrical synapses
  • M. Nomura, T. Fukai, T. Aoyagi
  • Proceedings of the 9th International Conference on Neural Information Processing, 2002. ICONIP '02.
  • 2002
We investigate the combined effects of electrical synapses (gap junctions) and GABAergic synapses on the synchronization of neuronal firing in a network of fast-spiking (FS) interneurons. We…
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