A network of dopaminergic gene variations implicated as risk factors for schizophrenia.

@article{Talkowski2008ANO,
  title={A network of dopaminergic gene variations implicated as risk factors for schizophrenia.},
  author={Michael E Talkowski and George Kirov and Mikhil Bamne and Lyudmila Georgieva and Gonzalo Torres and Hader Mansour and Kodavali V. Chowdari and Vihra K. Milanova and Joel Wood and Lora McClain and Konasale M. Prasad and Brian H. Shirts and Jianping Zhang and Michael C O'Donovan and Michael J Owen and Bernie J Devlin and Vishwajit L. Nimgaonkar},
  journal={Human molecular genetics},
  year={2008},
  volume={17 5},
  pages={747-58}
}
We evaluated the hypothesis that dopaminergic polymorphisms are risk factors for schizophrenia (SZ). In stage I, we screened 18 dopamine-related genes in two independent US Caucasian samples: 150 trios and 328 cases/501 controls. The most promising associations were detected with SLC6A3 (alias DAT), DRD3, COMT and SLC18A2 (alias VMAT2). In stage II, we comprehensively evaluated these four genes by genotyping 68 SNPs in all 478 cases and 501 controls from stage I. Fifteen (23.1%) significant… CONTINUE READING