A network of control mediated by regulator of calcium/calmodulin-dependent signaling.

@article{Rakhilin2004ANO,
  title={A network of control mediated by regulator of calcium/calmodulin-dependent signaling.},
  author={Sergey V Rakhilin and Patricia A. Olson and Akinori Nishi and Natalia N Starkova and Allen A. Fienberg and Angus C. Nairn and D James Surmeier and Paul Greengard},
  journal={Science},
  year={2004},
  volume={306 5696},
  pages={
          698-701
        }
}
Calmodulin (CaM) is a major effector for the intracellular actions of Ca2+ in nearly all cell types. We identified a CaM-binding protein, designated regulator of calmodulin signaling (RCS). G protein-coupled receptor (GPCR)-dependent activation of protein kinase A (PKA) led to phosphorylation of RCS at Ser55 and increased its binding to CaM. Phospho-RCS acted as a competitive inhibitor of CaM-dependent enzymes, including protein phosphatase 2B (PP2B, also called calcineurin). Increasing RCS… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 52 CITATIONS, ESTIMATED 68% COVERAGE

Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas

  • BMC Systems Biology
  • 2006
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2018

CITATION STATISTICS

  • 5 Highly Influenced Citations