Corpus ID: 14964186

A network model for cellular aging

  title={A network model for cellular aging},
  author={Hong Qin},
  journal={arXiv: Molecular Networks},
  • Hong Qin
  • Published 2013
  • Biology
  • arXiv: Molecular Networks
  • What is aging? Mechanistic answers to this question remain elusive despite decades of research. Here, we propose a mathematical model of cellular aging based on a model gene interaction network. Our network model is made of only non-aging components - the biological functions of gene interactions decrease with a constant mortality rate. Death of a cell occurs in the model when an essential gene loses all of its interactions to other genes, equivalent to the deletion of an essential gene. Gene… CONTINUE READING

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