Corpus ID: 14964186

A network model for cellular aging

@article{Qin2013ANM,
  title={A network model for cellular aging},
  author={Hong Qin},
  journal={arXiv: Molecular Networks},
  year={2013}
}
  • Hong Qin
  • Published 2013
  • Biology
  • arXiv: Molecular Networks
  • What is aging? Mechanistic answers to this question remain elusive despite decades of research. Here, we propose a mathematical model of cellular aging based on a model gene interaction network. Our network model is made of only non-aging components - the biological functions of gene interactions decrease with a constant mortality rate. Death of a cell occurs in the model when an essential gene loses all of its interactions to other genes, equivalent to the deletion of an essential gene. Gene… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES
    Cellular networks and the aging process
    • 24
    • PDF
    Protein networks, pleiotropy and the evolution of senescence
    • 130
    • PDF
    Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity
    • 115
    Aging cellular networks: Chaperones as major participants
    • 65
    • PDF
    A network biology approach to aging in yeast
    • 84
    • PDF
    Stochastic studies of aging and mortality in multi-cellular organisms. I. The asymptotic theory
    • 13
    In Brief
    • 261
    • PDF
    Robust Growth of Escherichia coli
    • 625