A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program.

@article{Hassan2010ANC,
  title={A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program.},
  author={Mohammad Quamarul Hassan and Jonathan A. R. Gordon and Marcio M Beloti and Carlo M. Croce and Andre J van Wijnen and Janet L Stein and Gary S Stein and Jane B Lian},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 46},
  pages={19879-84}
}
Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of genes that act as inhibitors of bone formation. How expression of bone-related miRs is regulated remains a compelling question. Here we report that Runx2, a transcription factor essential for osteoblastogenesis, negatively regulates expression of the miR cluster 23a∼27a∼24-2. Overexpression, reporter, and chromatin immunoprecipitation assays established the presence of a functional Runx binding element… CONTINUE READING