A network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases

@inproceedings{Fang2017ANM,
  title={A network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases},
  author={Hai-Yang Fang and Hua-Wu Zeng and Li-Mei Lin and Xing Chen and Xiao-Na Shen and Peng Fu and Chao Lv and Qun Liu and Run-hui Liu and W. M. Zhang and Jing Zhao},
  booktitle={Scientific reports},
  year={2017}
}
Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China. However, the complexity of composition and targets has deterred our understanding of its mechanism of action. Using network pharmacology-based approaches, we established the mechanism of action for SBP to treat CVD by analyzing protein-protein interactions and pathways. The computational results were confirmed at the gene expression level in microarray-based… CONTINUE READING
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