A network-assisted co-clustering algorithm to discover cancer subtypes based on gene expression

@inproceedings{Liu2013ANC,
  title={A network-assisted co-clustering algorithm to discover cancer subtypes based on gene expression},
  author={Yiyi Liu and Quanquan Gu and Jack P. Hou and Jiawei Han and Jian Ma},
  booktitle={BMC Bioinformatics},
  year={2013}
}
Cancer subtype information is critically important for understanding tumor heterogeneity. Existing methods to identify cancer subtypes have primarily focused on utilizing generic clustering algorithms (such as hierarchical clustering) to identify subtypes based on gene expression data. The network-level interaction among genes, which is key to understanding the molecular perturbations in cancer, has been rarely considered during the clustering process. The motivation of our work is to develop a… CONTINUE READING