A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.

@article{Sahlgren2006ANS,
  title={A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.},
  author={Cecilia Maria Sahlgren and Hanna-Mari Pallari and Tao He and Y H Chou and Robert D. Goldman and John E. Eriksson},
  journal={The EMBO journal},
  year={2006},
  volume={25 20},
  pages={4808-19}
}
The intermediate filament protein, nestin, has been implicated as an organizer of survival-determining signaling molecules. When nestin expression was related to the sensitivity of neural progenitor cells to oxidant-induced apoptosis, nestin displayed a distinct cytoprotective effect. Oxidative stress in neuronal precursor cells led to downregulation of nestin with subsequent activation of cyclin-dependent kinase 5 (Cdk5), a crucial kinase in the nervous system. Nestin downregulation was a… CONTINUE READING

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