A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses


Vaccine development and pathogenesis studies for human enterovirus 71 are limited by a lack of suitable animal models. Here, we report the development of a novel neonatal gnotobiotic pig model using the non-pig-adapted neurovirulent human enterovirus 71 strain BJ110, which has a C4 genotype. Porcine small intestinal epithelial cells, peripheral blood… (More)
DOI: 10.1038/emi.2014.35


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Citations per Year

Citation Velocity: 21

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