A negatively charged domain of LAT mediates its interaction with the active form of Lck.

@article{Kabouridis2011ANC,
  title={A negatively charged domain of LAT mediates its interaction with the active form of Lck.},
  author={Panagiotis S. Kabouridis and David Alan Isenberg and Elizabeth C. Jury},
  journal={Molecular membrane biology},
  year={2011},
  volume={28 7-8},
  pages={487-94}
}
We have shown previously that in T cells, LAT co-immunoprecipitates with the active but not the inactive-'closed' form of Lck, and that this interaction impacts negatively on Lck activity. Here we confirm that activation of T cells induced a transient LAT/Lck association within 4 min after stimulation, returning to basal levels by 30 min. Interestingly, autoimmune T cells isolated from patients with systemic lupus erythematosus, which contain a larger pool of active Lck and LAT, exhibited… CONTINUE READING
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