A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells.

@article{Casavant2013ANS,
  title={A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells.},
  author={Benjamin P. Casavant and Rachel Mosher and Jay W. Warrick and Lindsey J. Maccoux and Scott M. Berry and Jordan T Becker and Vivian Chen and Joshua Michael Lang and Douglas G. McNeel and David J. Beebe},
  journal={Methods},
  year={2013},
  volume={64 2},
  pages={
          137-43
        }
}
Circulating tumor cells (CTCs) exist in the peripheral blood stream of metastatic cancer patients at rates of approximately 1 CTC per billion background cells. In order to capture and analyze this rare cell population, various techniques exist that range from antibody-based surface marker positive selection to methods that use physical properties of CTCs to negatively exclude background cells from a CTC population. However, methods to capture cells for functional downstream analyses are limited… CONTINUE READING

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