A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.

@article{Young1993ANR,
  title={A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter.},
  author={Robert L. Young and Stanley J. Korsmeyer},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 6},
  pages={
          3686-97
        }
}
bcl-2 mRNA is present at high levels in pre-B-cell lines but is down-regulated in most mature B-cell lines. To investigate the mechanisms responsible for its developmental control, we studied the regulation of bcl-2 expression in human B-lineage cell lines. Using nuclear run-on assays, we found that bcl-2 transcription decreases in parallel with levels of steady-state mRNA during B-cell development. To define cis-acting elements that regulate bcl-2 transcription, we analyzed the expression of… CONTINUE READING

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