A negative regulator of telomere-length protein trf1 is associated with interstitial (TTAGGG)n blocks in immortal Chinese hamster ovary cells.

@article{Krutilina2001ANR,
  title={A negative regulator of telomere-length protein trf1 is associated with interstitial (TTAGGG)n blocks in immortal Chinese hamster ovary cells.},
  author={Raisa Ivanovna Krutilina and S L Oei and G Buchlow and Peter Yau and Andrey Olegovich Zalensky and Irina A. Zalenskaya and E. Morton Bradbury and Nikolai Viktorovich Tomilin},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={280 2},
  pages={471-5}
}
Telomeres of mammalian chromosomes are composed of long tandem repeats (TTAGGG)n which bind in a sequence-specific manner two proteins-TRF1 and TRF2. In human somatic cells both proteins are mostly associated with telomeres and TRF1 overexpression resulting in telomere shortening. However, chromosomes of some mammalian species, e.g., Chinese hamster, have large interstitial blocks of (TTAGGG)n sequence (IBTs) and the blocks are involved in radiation-induced chromosome instability. In normal… CONTINUE READING
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