A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors

Abstract

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect is unrelated to β-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP. 
DOI: 10.1007/BF01967963

3 Figures and Tables

Topics

  • Presentations referencing similar topics