A negative feedback signaling network underlies oncogene-induced senescence.

  title={A negative feedback signaling network underlies oncogene-induced senescence.},
  author={St{\'e}phanie Courtois-Cox and Sybil M Genther Williams and Elizabeth E. Reczek and Bryan W. Johnson and Lauren T McGillicuddy and Cory M. Johannessen and Pablo E. Hollstein and Mia Maccollin and Karen Cichowski},
  journal={Cancer cell},
  volume={10 6},
Oncogene-induced senescence functions to limit tumor development. However, a complete understanding of the signals that trigger this type of senescence is currently lacking. We found that mutations affecting NF1, Raf, and Ras induce a global negative feedback response that potently suppresses Ras and/or its effectors. Moreover, these signals promote senescence by inhibiting the Ras/PI3K pathway, which can impact the senescence machinery through HDM2 and FOXO. This negative feedback program is… CONTINUE READING
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