A negative feedback signaling network underlies oncogene-induced senescence.

@article{CourtoisCox2006ANF,
  title={A negative feedback signaling network underlies oncogene-induced senescence.},
  author={St{\'e}phanie Courtois-Cox and Sybil M Genther Williams and Elizabeth E. Reczek and Bryan Walter Johnson and Lauren Terese McGillicuddy and Cory M Johannessen and Pablo E. Hollstein and Mia M Maccollin and Karen Cichowski},
  journal={Cancer cell},
  year={2006},
  volume={10 6},
  pages={
          459-72
        }
}
Oncogene-induced senescence functions to limit tumor development. However, a complete understanding of the signals that trigger this type of senescence is currently lacking. We found that mutations affecting NF1, Raf, and Ras induce a global negative feedback response that potently suppresses Ras and/or its effectors. Moreover, these signals promote senescence by inhibiting the Ras/PI3K pathway, which can impact the senescence machinery through HDM2 and FOXO. This negative feedback program is… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 228 CITATIONS, ESTIMATED 57% COVERAGE

419 Citations

02040'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 419 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

, tumor suppression , and organismal aging : Good citizens , bad neighbors

  • Z. Chen, L. C. Trotman, +7 authors W. Gerald
  • 2005
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…